Chua T P, Coats A J
Department of Cardiac Medicine, Royal Brompton National Heart & Lung Institute, London, UK.
Eur J Clin Invest. 1995 Dec;25(12):887-92. doi: 10.1111/j.1365-2362.1995.tb01962.x.
Both the transient hypoxic ventilatory drive test and the single-breath carbon dioxide (CO2) response test have been used to assess peripheral chemoreflex sensitivity. We tested their comparability in 14 healthy adults (10 men, aged 31-73 years, mean 55.4 years). The within-subject reproducibility of both tests was also assessed (n = 7 for each). The mean transient hypoxic ventilatory response was 0.287 +/- 0.0591 min-1 (%Sao2)-1 (mean +/- SEM, range 0.018- 0.718) and single-breath CO2 response was 0.276 +/- 0.0411 min-1T-1 (range 0.081-0.501). Both tests were reproducible with a mean coefficient of variation of 20.1% and 17.7%, respectively. There was, however, no significant correlation between the results of the transient hypoxic and single-breath CO2 tests when data were compared by linear regression analysis (r = 0.23, P = 0.43), suggesting that separate pathways of the peripheral chemoreflex existed for hypoxia and hypercapnia, respectively, and that these tests were specific for each. The authors conclude that these tests are reproducible but need to be used in combination for an adequate assessment of the peripheral chemoreflex.
瞬态低氧通气驱动试验和单次呼吸二氧化碳（CO₂）反应试验均已用于评估外周化学反射敏感性。我们在14名健康成年人（10名男性，年龄31 - 73岁，平均55.4岁）中测试了它们的可比性。还评估了两种试验在受试者内的可重复性（每种试验n = 7）。平均瞬态低氧通气反应为0.287 +/- 0.0591 min⁻¹（%Sao₂）⁻¹（平均值 +/- 标准误，范围0.018 - 0.718），单次呼吸CO₂反应为0.276 +/- 0.0411 min⁻¹T⁻¹（范围0.081 - 0.501）。两种试验均可重复，平均变异系数分别为20.1%和17.7%。然而，当通过线性回归分析比较数据时，瞬态低氧试验和单次呼吸CO₂试验的结果之间无显著相关性（r = 0.23，P = 0.43），这表明外周化学反射分别存在针对低氧和高碳酸血症的不同途径，并且这些试验对每种情况具有特异性。作者得出结论，这些试验具有可重复性，但需要联合使用以充分评估外周化学反射。
