Bhatnagar A, Singh A K, Singh T, Shankar L R
Department of Nuclear Medicine, Institute of Nuclear Medicine and Allied Sciences, Lucknow Marg, Delhi, India.
Nucl Med Commun. 1995 Dec;16(12):1058-62.
The aim of this study was to test whether 99Tcm-dextran can be used for imaging inflammation. An in vivo inflammation model was prepared by intramuscular (i.m.) injection of Freund's complete adjuvant to the thigh of five rabbits. Serial imaging of the animals was done with 99Tcm-dextran for 2 weeks following the onset of inflammation. The radiotracer was seen to concentrate selectively in the lesion, with a mean target-to-nontarget ratio of 3.01 (range 2.74-3.15) from day 4 onwards. The area of scintiscan abnormality increased with time and was more marked than the physical appearance of the lesion. In two rabbits, the tracer was also seen to localize at the site of injection of the anaesthesia in the normal thigh. The best time to image was found to be 2-4 h after 99Tcm-dextran administration. It would appear that abnormally increased capillary permeability in the inflamed area results in enhanced uptake of the macromolecule. We conclude that 99Tcm-dextran is a potential inflammation-seeking radiotracer, though it needs to be evaluated further.
本研究的目的是测试99锝-葡聚糖是否可用于炎症显像。通过向5只兔子的大腿肌肉内注射弗氏完全佐剂制备了一种体内炎症模型。在炎症发作后的2周内，用99锝-葡聚糖对动物进行连续显像。从第4天起，放射性示踪剂选择性地在病变部位聚集，平均靶非靶比值为3.01（范围为2.74 - 3.15）。闪烁扫描异常区域随时间增加，且比病变的外观更明显。在两只兔子中，还观察到示踪剂在正常大腿的麻醉注射部位定位。发现显像的最佳时间是在注射99锝-葡聚糖后2 - 4小时。似乎炎症区域毛细血管通透性异常增加导致大分子摄取增强。我们得出结论，99锝-葡聚糖是一种潜在的炎症靶向放射性示踪剂，尽管它需要进一步评估。
