Bhatnagar A, Singh A K, Lahoti D, Singh T, Khanna C M
Department of Nuclear Medicine, Institute of Nuclear Medicine and Allied Sciences, Delhi, India.
Eur J Nucl Med. 1996 May;23(5):575-8. doi: 10.1007/BF00833395.
The purpose of this study was to evaluate technetium-99m dextran (99mTc-Dx; molecular weight 81000) as a prospective protein-losing enteropathy (PLE) imaging agent. Twenty-two patients with diseases commonly associated with PLE and 12 healthy control subjects underwent intravenous 99mTc-Dx scintigraphy. All of the 22 test patients showed significant radiotracer accumulation in the intestines within 3-4 h post injection. The focal, regional or generalised nature of the enteropathy and involvement of the large or small intestine could be identified in most cases. Four of the 12 apparently healthy subjects also showed minimal accumulation in the abdominal area occurring late in the study period. This could have been physiological, related to food habits or due to unsuspected intestinal worms. We attribute the high sensitivity of 99mTc-Dx to its relatively fast blood (background) clearance. The radiotracer may have several other advantages over 99mTc-labelled human serum albumin in imaging PLE.
本研究的目的是评估锝-99m葡聚糖（99mTc-Dx；分子量81000）作为一种潜在的蛋白丢失性肠病（PLE）显像剂。22例患有通常与PLE相关疾病的患者和12名健康对照者接受了静脉注射99mTc-Dx闪烁扫描。22例受试患者在注射后3 - 4小时内均显示肠道有明显的放射性示踪剂聚集。在大多数情况下，可以确定肠病的局灶性、区域性或全身性性质以及大肠或小肠的受累情况。12名表面健康的受试者中有4名在研究后期也显示腹部有少量聚集。这可能是生理性的，与饮食习惯有关，或者是由于未被怀疑的肠道寄生虫。我们将99mTc-Dx的高敏感性归因于其相对较快的血液（本底）清除率。在PLE显像方面，该放射性示踪剂可能比99mTc标记的人血清白蛋白具有其他几个优势。
