Masuda M, Haresaku M, Takei T, Nakamura T
Human Safety Evaluation Center, Research and Development Headquarters, Lion Corporation, Kanagawa, Japan.
J Toxicol Sci. 1995 Nov;20(5):619-27. doi: 10.2131/jts.20.5_619.
The mutagenicity of palm fruit carotene was examined using the reverse mutation test with bacteria, the chromosomal aberration test with mammalian cells and the micronucleus test in mice. The carotene induced neither reverse mutation in Salmonella typhimurium TA98, TA1537, TA100, TA1535 and in Escherichia coli WP2uvrA, nor structural and numerical (polyploidy) chromosomal aberrations in the Chinese hamster fibroblast cell line (CHL). In addition, no increase in micronucleated polychromatic erythrocytes was elicited in the micronucleus test in CD-1(ICR) male mice. It is concluded that palm fruit carotene had no mutagenic activity in these in vitro and in vivo tests.
利用细菌回复突变试验、哺乳动物细胞染色体畸变试验以及小鼠微核试验，对棕榈果胡萝卜素的致突变性进行了检测。该胡萝卜素在鼠伤寒沙门氏菌TA98、TA1537、TA100、TA1535以及大肠杆菌WP2uvrA中均未诱导回复突变，在中国仓鼠成纤维细胞系（CHL）中也未诱导结构和数量（多倍体）染色体畸变。此外，在CD-1（ICR）雄性小鼠的微核试验中，未引起微核多染红细胞数量增加。得出的结论是，在这些体外和体内试验中，棕榈果胡萝卜素没有致突变活性。
