Sensch K H, Zeiller P, Raake W
Arzneimittelforschung. 1979;29(1):116-21.
The anti-exudative and anti-edematous effects and the dose-effect relationship of a-sympathomimetics, especially of l-phenylephrine-HCl (PE), have been demonstrated using as model the rat pad-carrageenan edema and the histamine liberator test, the dosage being administered cutaneously, orally, and intraperitoneally. The beta-receptor activating compound bamethane sulfate was not effective when used on the same models. Evidence of percutaneous penetration of PE was provided both on isolated skin and in viro. PE, when injected intravenously or subcutaneously, produced a rise of blood pressure in experimental animals. When PE was administered orally and cutaneously, it did not, however, alter the blood pressure. The anti-inflammatory and anti-exudative effects remianed unchanged.
以大鼠足跖角叉菜胶性水肿和组胺释放试验为模型，通过皮肤、口服和腹腔内给药，已证明了α-拟交感神经药，尤其是盐酸去氧肾上腺素（PE）的抗渗出和抗水肿作用及其剂量效应关系。β受体激动化合物硫酸巴美生在相同模型上无效。在离体皮肤和体内均证实了PE的经皮渗透。当给实验动物静脉内或皮下注射PE时，会使其血压升高。然而，当口服和经皮给予PE时，并未改变血压。其抗炎和抗渗出作用保持不变。
