Kiyosawa M, Inoue C, Kawasaki T, Tokoro T, Ishii K, Ohyama M, Senda M, Soma Y
Department of Ophthalmology, Tokyo Medical and Dental University, School of Medicine, Japan.
Graefes Arch Clin Exp Ophthalmol. 1996 Feb;234(2):110-5. doi: 10.1007/BF00695250.
The ability to name objects depends partly on visual perception. We used positron emission tomography (PET) to measure activity-related changes in regional cerebral blood flow (r-CBF) in order to identify regions of the brain activated during visual object naming.
Four right-handed volunteers were recruited. Following an intravenous injection of 15O-labeled water, r-CBF was measured during visual object naming, counting numbers, and resting. PET and MRI images were coregistered, the size of the brain was proportionally adjusted in each axis to Talairach's and Tournoux's atlas, and the comparison of stimulated versus resting blood flow images revealed activated brain regions.
In the subtraction of resting from naming, activation was observed in the bilateral primary visual cortex, bilateral fusiform gyrus, left lingual gyrus, bilateral inferotemporal cortex, bilateral inferior frontal gyrus, bilateral precentral gyrus, anterior cingulate gyrus, left parietal operculum, and left putamen. In the subtraction of counting from naming, most of the those areas were activated, but no significant activity was observed in the left lingual gyrus, left parietal operculum, or bilateral precentral gyrus (motor cortex). The areas activated with the paradigm included those dedicated to visual perception (primary and associate visual cortex), visual recognition (inferior temporal cortex), and phonological output (Broca's area).
Our results indicated that the major neural network from occipital lobe to frontal cortex, which is mainly involved in the ventral visual pathway, demonstrated activation in these tasks. Result of this study will serve as base line data for analyzing the findings in patients with impaired visual perception.
命名物体的能力部分取决于视觉感知。我们使用正电子发射断层扫描（PET）来测量与活动相关的局部脑血流量（r-CBF）变化，以识别视觉物体命名过程中大脑激活的区域。
招募了四名右利手志愿者。静脉注射15O标记水后，在视觉物体命名、数数和休息期间测量r-CBF。PET和MRI图像进行配准，大脑尺寸在每个轴向上按比例调整为Talairach和Tournoux图谱的尺寸，刺激血流图像与静息血流图像的比较揭示了激活的脑区。
在命名与静息状态的减法运算中，双侧初级视觉皮层、双侧梭状回、左侧舌回、双侧颞下回、双侧额下回、双侧中央前回、前扣带回、左侧顶叶岛盖和左侧壳核观察到激活。在命名与数数的减法运算中，这些区域大多被激活，但在左侧舌回、左侧顶叶岛盖或双侧中央前回（运动皮层）未观察到显著活动。该范式激活的区域包括那些专门用于视觉感知（初级和联合视觉皮层）、视觉识别（颞下回）和语音输出（布洛卡区）的区域。
我们的结果表明，主要参与腹侧视觉通路的从枕叶到额叶皮层的主要神经网络在这些任务中表现出激活。本研究结果将作为分析视觉感知受损患者研究结果的基线数据。
