Bengtsson C, Lapidus L
Department of Primary Health Care and Medicine, University of Göteborg, Gothenburg, Sweden.
Scott Med J. 1994 Jun;39(3):71-3. doi: 10.1177/003693309403900304.
Felodipine, a vascular selective antihypertensive calcium antagonist, was compared with hydrochlorothiazide, a diuretic, with respect to glucose tolerance. An open crossover study was performed comprising 16 non-diabetic hypertensive women (age range 59-75 years). The women continued to take a beta-blocker as a basal therapy. Each treatment period lasted three months. The blood pressure was similar irrespective of treatment. Blood glucose values were not significantly different during the oral glucose tolerance test. Serum insulin levels after glucose administration were lower when the patients were treated with felodipine than when taking hydrochlorothiazide. A possible explanation for this observation may be an increased insulin release as a consequence of treatment with a diuretic in order to maintain normal blood glucose levels during the glucose tolerance test. Felodipine appears preferable to hydrochlorothiazide as an addition to a beta blocker in hypertensive patients from a glucose metabolism point of view.
非洛地平是一种血管选择性降压钙拮抗剂，就糖耐量而言，将其与利尿剂氢氯噻嗪进行了比较。对16名非糖尿病高血压女性（年龄范围59 - 75岁）进行了一项开放性交叉研究。这些女性继续服用β受体阻滞剂作为基础治疗。每个治疗期持续三个月。无论采用何种治疗，血压相似。口服葡萄糖耐量试验期间的血糖值无显著差异。服用非洛地平治疗的患者在给予葡萄糖后的血清胰岛素水平低于服用氢氯噻嗪时。对此观察结果的一种可能解释可能是，在葡萄糖耐量试验期间，为维持正常血糖水平，利尿剂治疗导致胰岛素释放增加。从葡萄糖代谢的角度来看，在高血压患者中，作为β受体阻滞剂的辅助用药，非洛地平似乎比氢氯噻嗪更可取。
