核糖体中5S rRNA的结构与功能。

Structure and function of 5S rRNA in the ribosome.

作者信息

Bogdanov A A, Dontsova O A, Dokudovskaya S S, Lavrik I N

机构信息

Department of Chemistry of Natural Compounds, School of Chemistry, Moscow State University, Russia.

出版信息

Biochem Cell Biol. 1995 Nov-Dec;73(11-12):869-76. doi: 10.1139/o95-094.

DOI:10.1139/o95-094

PMID:8722002

Abstract

5S rRNA is a small RNA molecule that is a component of a ribosome from almost all living organisms. In this review, we discuss the biogenesis of 5S rRNA and its properties as an independent structural domain of a ribosome as well as the current concepts concerning the higher order structure of 5S rRNA in free state and in its complexes with ribosomal proteins and its folding in the ribosome. Special attention is paid to recent experimental approaches that have been useful in 5S rRNA studies. Our own data on topography of 5S rRNA in the ribosomes are discussed in detail. The hypothesis describing the possible functional role of 5S rRNA for ribosome functioning is discussed.

摘要

5S核糖体RNA是一种小分子RNA，几乎存在于所有生物体的核糖体中。在这篇综述中，我们讨论了5S核糖体RNA的生物合成及其作为核糖体独立结构域的特性，以及目前关于游离状态下5S核糖体RNA及其与核糖体蛋白复合物的高级结构和其在核糖体中的折叠的概念。特别关注了最近在5S核糖体RNA研究中有用的实验方法。我们自己关于核糖体中5S核糖体RNA拓扑结构的数据也进行了详细讨论。还讨论了描述5S核糖体RNA对核糖体功能可能发挥的作用的假说。