Department of Microbiology and Immunology, University at Buffalo, Buffalo, NY, USA.
Wiley Interdiscip Rev RNA. 2011 Jul-Aug;2(4):523-33. doi: 10.1002/wrna.74. Epub 2011 Feb 25.
The ribosome is a large complex containing both protein and RNA which must be assembled in a precise manner to allow proper functioning in the critical role of protein synthesis. 5S rRNA is the smallest of the RNA components of the ribosome, and although it has been studied for decades, we still do not have a clear understanding of its function within the complex ribosome machine. It is the only RNA species that binds ribosomal proteins prior to its assembly into the ribosome. Its transport into the nucleolus requires this interaction. Here we present an overview of some of the key findings concerning the structure and function of 5S rRNA and how its association with specific proteins impacts its localization and function.
核糖体是一种包含蛋白质和 RNA 的大型复合物，必须以精确的方式组装，以使其在蛋白质合成这一关键作用中正常发挥功能。5S rRNA 是核糖体 RNA 成分中最小的一种，尽管它已经被研究了几十年，但我们仍然不清楚它在复杂的核糖体机器中的功能。它是唯一在装配到核糖体之前与核糖体蛋白结合的 RNA 种类。其进入核仁的运输需要这种相互作用。在这里，我们概述了一些关于 5S rRNA 的结构和功能的关键发现，以及其与特定蛋白质的关联如何影响其定位和功能。
