Wool I G, Chan Y L, Glück A
Department of Biochemistry and Molecular Biology, University of Chicago, IL 60637, USA.
Biochem Cell Biol. 1995 Nov-Dec;73(11-12):933-47. doi: 10.1139/o95-101.
Mammalian (rat) ribosomes have 80 proteins; the sequence of amino acids in 75 have been determined. What has been learned of the structure of the rat ribosomal proteins is reviewed with particular attention to their evolution and to amino acid sequence motifs. The latter include: clusters of basic or acidic residues; sequence repeats or shared sequences; zinc finger domains; bZIP elements; and nuclear localization signals. The occurrence and the possible significance of phosphorylated residues and of ubiquitin extensions is noted. The characteristics of the mRNAs that encode the proteins are summarized. The relationship of the rat ribosomal proteins to the proteins in ribosomes from humans, yeast, archaebacteria, and Escherichia coli is collated.
哺乳动物（大鼠）核糖体有80种蛋白质；其中75种蛋白质的氨基酸序列已被确定。本文综述了关于大鼠核糖体蛋白质结构的研究成果，特别关注它们的进化以及氨基酸序列基序。后者包括：碱性或酸性残基簇；序列重复或共享序列；锌指结构域；碱性亮氨酸拉链元件；以及核定位信号。文中还提到了磷酸化残基和泛素延伸的出现情况及其可能的意义。总结了编码这些蛋白质的mRNA的特征。整理了大鼠核糖体蛋白质与人类、酵母、古细菌和大肠杆菌核糖体中蛋白质的关系。
