Reed R
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Curr Opin Genet Dev. 1996 Apr;6(2):215-20. doi: 10.1016/s0959-437x(96)80053-0.
Advances over the past year have provided new insights into the mechanisms involved in the initial recognition and pairing of the 5' and 3' splice sites in complex metazoan pre-mRNAs. Highlights include the demonstration that exonic enhancers can promote trans splicing and that an excess of the serine and arginine rich family of splicing proteins can obviate the requirement for U1 small nuclear ribonucleoprotein particle in splicing.
过去一年的研究进展为深入了解复杂后生动物前体mRNA中5'和3'剪接位点的初始识别和配对机制提供了新的见解。其中的亮点包括：证明外显子增强子可促进反式剪接，以及富含丝氨酸和精氨酸的剪接蛋白家族过量时可消除剪接过程中对U1小核核糖核蛋白颗粒的需求。
