剪接与切割：内含子微小RNA、剪接与癌症
Splice and Dice: Intronic microRNAs, Splicing and Cancer.
作者信息
Wong Alex C H, Rasko John E J
机构信息
Gene & Stem Cell Therapy Program, Centenary Institute, University of Sydney, Camperdown 2050, Australia.
Sydney Medical School, University of Sydney, Sydney 2006, Australia.
出版信息
Biomedicines. 2021 Sep 19;9(9):1268. doi: 10.3390/biomedicines9091268.
Introns span only a quarter of the human genome, yet they host around 60% of all known microRNAs. Emerging evidence indicates the adaptive advantage of microRNAs residing within introns is attributed to their complex co-regulation with transcription and alternative splicing of their host genes. Intronic microRNAs are often co-expressed with their host genes, thereby providing functional synergism or antagonism that is exploited or decoupled in cancer. Additionally, intronic microRNA biogenesis and the alternative splicing of host transcript are co-regulated and intertwined. The importance of intronic microRNAs is under-recognized in relation to the pathogenesis of cancer.
内含子仅占人类基因组的四分之一，但却包含了约60%的已知微小RNA。新出现的证据表明，位于内含子中的微小RNA的适应性优势归因于它们与其宿主基因的转录和可变剪接的复杂共同调控。内含子微小RNA通常与其宿主基因共表达，从而在癌症中提供功能协同或拮抗作用，这种作用在癌症中被利用或解耦。此外，内含子微小RNA的生物合成和宿主转录本的可变剪接是共同调控且相互交织的。与癌症发病机制相关的内含子微小RNA的重要性尚未得到充分认识。
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