Rune S J
Dept. of Gastroenterology, Glostrup University Hospital, Denmark.
Scand J Gastroenterol Suppl. 1996;214:2-4; discussion 9-12.
Helicobacter pylori infection is now recognized as the cause of most cases of chronic gastritis, and a major causal factor in peptic ulcer disease. However, though the presence of intragastric bacteria has been recognized for many years, the connection between H. pylori and peptic ulcers has only been established during the last decade. Pathological studies have suggested that intragastric bacteria damage the gastric mucosa, reducing its resistance to acid, while epidemiological studies have suggested that a non-physiological factor, such as bacterial infection, is involved in the development of peptic ulcer. Subsequently, H. pylori, associated with chronic gastritis, was identified in gastric biopsies from patients with peptic ulcer. Eradication of H. pylori has been shown to reduce the recurrence of peptic ulcer after ulcer healing, and such treatment is now widely accepted.
幽门螺杆菌感染目前被认为是大多数慢性胃炎病例的病因，也是消化性溃疡疾病的主要致病因素。然而，尽管胃内细菌的存在已被认识多年，但幽门螺杆菌与消化性溃疡之间的联系直到过去十年才得以确立。病理研究表明，胃内细菌会损害胃黏膜，降低其对酸的抵抗力，而流行病学研究则表明，诸如细菌感染等非生理因素参与了消化性溃疡的发生发展。随后，在消化性溃疡患者的胃活检中发现了与慢性胃炎相关的幽门螺杆菌。根除幽门螺杆菌已被证明可降低溃疡愈合后消化性溃疡的复发率，这种治疗方法现已被广泛接受。
