Kerscher M J, Korting H C, Mehringer L, Mätzig R
Dermatologische Klinik, Ludwig-Maximilians-Universität, München, Deutschland.
Skin Pharmacol. 1996;9(2):120-3. doi: 10.1159/000211407.
Repeated open application of clobetasol 17-propionate cream and ointment to normal skin over a period of 6 weeks induced an increase in skin surface roughness as assessed by profilometry (p < 0.05), while 6 weeks' application of triamcinolone acetonide cream and ointment did not. The increase in skin roughness with clobetasol 17-propionate cream turned out to be greater than with ointment containing identical amounts of clobetasol 17-propionate (p < 0.05). A clear-cut correlation between increase of skin surface roughness and skin thickness as assessed by high-frequency ultrasound could be demonstrated only with clobetasol 17-propionate cream and ointment.
在6周的时间里，对正常皮肤反复外用丙酸氯倍他索乳膏和软膏，通过轮廓仪评估发现皮肤表面粗糙度增加（p < 0.05），而外用曲安奈德乳膏和软膏6周则未出现这种情况。结果表明，丙酸氯倍他索乳膏导致的皮肤粗糙度增加大于含等量丙酸氯倍他索的软膏（p < 0.05）。仅在丙酸氯倍他索乳膏和软膏中，通过高频超声评估发现皮肤表面粗糙度增加与皮肤厚度之间存在明确的相关性。
