系统性红斑狼疮患者使用硫酸葡聚糖纤维素柱吸附选择性去除后抗DNA抗体动力学
Anti-DNA antibody kinetics following selective removal by adsorption using dextran sulphate cellulose columns in patients with systemic lupus erythematosus.
作者信息
Suzuki K, Matsuki Y, Hidaka T, Ishizuka T, Kawakami M, Takata S, Kutsuki H, Nakamura H
机构信息
National Defense Medical College, Saitama, Japan.
出版信息
J Clin Apher. 1996;11(1):16-22. doi: 10.1002/(SICI)1098-1101(1996)11:1<16::AID-JCA4>3.0.CO;2-E.
The aim of this study is to determine by mathematical analysis which of two models, the one- or the two-compartment model, more closely approximates the kinetics of anti-dsDNA following immunoadsorption procedures in patients with systemic lupus erythematosus. Titers of anti-dsDNA were measured at specified intervals after apheresis to each model by nonlinear least-squares methods, and Akaike's Information Criterion (AIC) was calculated to determine which model most approximately described the kinetics. The AIC of the two-compartment model was larger than that of the one-compartment model in all 14 SLE patients (P < .001). Therefore, the one-compartment model is thought to be suitable. The generation rate and catabolic rate of anti-dsDNA were obtainable using this model. The anti-dsDNA replenishment curve after an immunoadsorption session was defined by only two parameters: the generation and catabolic rates of anti-dsDNA.
本研究的目的是通过数学分析确定两种模型（一室模型或二室模型）中的哪一种更接近系统性红斑狼疮患者免疫吸附程序后抗双链DNA的动力学。通过非线性最小二乘法在每次单采后按特定时间间隔测量各模型的抗双链DNA滴度，并计算赤池信息准则（AIC）以确定哪种模型最能近似描述动力学。在所有14例系统性红斑狼疮患者中，二室模型的AIC均大于一室模型（P <.001）。因此，一室模型被认为是合适的。使用该模型可获得抗双链DNA的生成率和分解代谢率。免疫吸附疗程后的抗双链DNA补充曲线仅由两个参数定义：抗双链DNA的生成率和分解代谢率。
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