在系统性红斑狼疮患者中，使用硫酸葡聚糖柱通过吸附性血浆置换选择性去除抗DNA和抗心磷脂抗体。
Selective removal of anti-DNA and anticardiolipin antibodies by adsorbent plasmapheresis using dextran sulfate columns in patients with systemic lupus erythematosus.
作者信息
Hashimoto H, Tsuda H, Kanai Y, Kobayashi S, Hirose S, Shinoura H, Yokohari R, Kinoshita M, Aotsuka S, Yamada H
机构信息
Juntendo University, Department of Internal Medicine and Rheumatology, Tokyo, Japan.
出版信息
J Rheumatol. 1991 Apr;18(4):545-51.
The effect of adsorbent plasmapheresis using dextran sulfate columns on anti-DNA and/or anticardiolipin antibodies (aCL) in 6 patients with systemic lupus erythematosus (SLE) was studied by multicenter clinical trials. The titers of anti-DNA (RI assay), IgG anti-dsDNA (ELISA), IgG and/or IgM anti-ssDNA, (ELISA), and IgG aCL (ELISA) significantly decreased or normalized after 4 treatments of plasmapheresis during a 2 to 4 week period. A patient with SLE with recurrent abortion and aCL who was successfully treated by adsorbent plasmapheresis is reported. We expect that adsorbent plasmapheresis will be an influential treatment for patients with not only SLE but aCL syndrome.
通过多中心临床试验研究了使用硫酸葡聚糖柱进行吸附性血浆置换对6例系统性红斑狼疮（SLE）患者抗DNA和/或抗心磷脂抗体（aCL）的影响。在2至4周内进行4次血浆置换治疗后，抗DNA（RI检测法）、IgG抗双链DNA（ELISA法）、IgG和/或IgM抗单链DNA（ELISA法）以及IgG aCL（ELISA法）的滴度显著降低或恢复正常。报告了1例患有复发性流产和aCL的SLE患者通过吸附性血浆置换成功治疗的病例。我们期望吸附性血浆置换不仅对SLE患者，而且对aCL综合征患者都将是一种有影响力的治疗方法。
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