单个P因子插入对黑腹果蝇嗅觉行为的影响。
Effects of single P-element insertions on olfactory behavior in Drosophila melanogaster.
作者信息
Anholt R R, Lyman R F, Mackay T F
机构信息
Department of Zoology, North Carolina State University, Raleigh 27695, USA.
出版信息
Genetics. 1996 May;143(1):293-301. doi: 10.1093/genetics/143.1.293.
Abstract
Single P-element (P[lArB]) insertional mutagenesis of an isogenic strain was used to identify autosomal loci affecting odor-guided behavior of Drosophila melanogaster. The avoidance response to benzaldehyde of 379 homozygous P[lArB] element-containing insert lines was evaluated quantitatively. Fourteen smell impaired (smi) lines were identified in which P[lArB] element insertion caused different degrees of hyposmia in one or both sexes. The smi loci map to different cytological locations and probably are novel olfactory genes. Enhancer trap analysis of the smi lines indicates that expression of at least 10 smi genes is controlled by olfactory tissue-specific promoter/enhancer elements.
摘要
利用同基因品系的单个P因子（P[lArB]）插入诱变来鉴定影响黑腹果蝇气味引导行为的常染色体基因座。对379个含有纯合P[lArB]因子插入系的苯甲醛回避反应进行了定量评估。鉴定出14个嗅觉受损（smi）系，其中P[lArB]因子插入在一个性别或两个性别中导致不同程度的嗅觉减退。smi基因座定位于不同的细胞学位置，可能是新的嗅觉基因。对smi系的增强子陷阱分析表明，至少10个smi基因的表达受嗅觉组织特异性启动子/增强子元件控制。
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