Bourguet D, Prout M, Raymond M
Institut des Sciences de l'Evolution, Université Montpellier II, France.
Genetics. 1996 May;143(1):407-16. doi: 10.1093/genetics/143.1.407.
Dominance level of insecticide resistance provided by one major gene (an insensitive acetylcholinesterase) in the mosquito Culex pipiens was studied in two distinct environments. Dominance level was found to be very different environments, varying from almost complete dominance to almost recessive when either propoxur (a carbamate insecticide) or chlorpyrifos (an organophosphorus insecticide) was used. To better understand this plastic response, three environmental parameters were manipulated and their interactions studied. For chlorpyrifos, each parameter had a small effect, but when all parameters were changed, the dominance level was greatly affected. For propoxur, one environmental parameter had a large effect by itself. It was further studied to understand the causal relationship of this plasticity. Recessivity of resistance was associated with more demanding environments. These results are discussed in the context of the various theories of the evolution of dominance. It appears that dominance of insecticide resistance cannot be directly predicted by Wright's physiological theory.
在两个不同环境中研究了致倦库蚊中一个主要基因（一种不敏感的乙酰胆碱酯酶）所赋予的抗杀虫剂显性水平。发现显性水平在不同环境中差异很大，当使用残杀威（一种氨基甲酸酯类杀虫剂）或毒死蜱（一种有机磷杀虫剂）时，显性水平从几乎完全显性到几乎隐性不等。为了更好地理解这种可塑性反应，对三个环境参数进行了调控并研究了它们之间的相互作用。对于毒死蜱，每个参数的影响较小，但当所有参数都改变时，显性水平受到很大影响。对于残杀威，一个环境参数本身就有很大影响。进一步研究以了解这种可塑性的因果关系。抗性的隐性与要求更高的环境相关。在显性进化的各种理论背景下讨论了这些结果。看来杀虫剂抗性的显性不能直接用赖特的生理学理论来预测。
