Hwang J H, Graham G D, Behar K L, Alger J R, Prichard J W, Rothman D L
Department of Neurology, Yale Medical School, New Haven, CT 06520-8043, USA.
Magn Reson Med. 1996 May;35(5):633-9. doi: 10.1002/mrm.1910350502.
A novel approach is presented for imaging macromolecule and metabolite signals in brain by proton magnetic resonance spectroscopic imaging. The method differentiates between metabolites and macromolecules by T1 weighting using an inversion pulse followed by a variable inversion recovery time before localization and spectroscopic imaging. In healthy subjects, the major macromolecule resonances at 2.05 and 0.9 ppm were mapped at a nominal spatial resolution of 1 x 1 x 1.5 cm3 and were demonstrated to be highly reproducible between subjects. In subacute stroke patients, a highly elevated macromolecule resonance at 1.3 ppm was mapped to infarcted brain regions, suggesting potential applications for studying pathological conditions.
本文提出了一种通过质子磁共振波谱成像对大脑中的大分子和代谢物信号进行成像的新方法。该方法通过使用反转脉冲进行T1加权，然后在定位和波谱成像之前采用可变反转恢复时间来区分代谢物和大分子。在健康受试者中，2.05 ppm和0.9 ppm处的主要大分子共振以1×1×1.5 cm3的标称空间分辨率进行了映射，并被证明在受试者之间具有高度可重复性。在亚急性中风患者中，1.3 ppm处高度升高的大分子共振被映射到梗死脑区，表明该方法在研究病理状况方面具有潜在应用价值。
