产超广谱头孢菌素的阴沟肠杆菌耐药变异体的差异。
Differences in the resistant variants of Enterobacter cloacae selected by extended-spectrum cephalosporins.
作者信息
Fung-Tomc J C, Gradelski E, Huczko E, Dougherty T J, Kessler R E, Bonner D P
机构信息
Department of Microbiology, Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut 06492, USA.
出版信息
Antimicrob Agents Chemother. 1996 May;40(5):1289-93. doi: 10.1128/AAC.40.5.1289.
Abstract
The rates of development of resistance to ceftriaxone, ceftazidime, cefepime, and cefpirome in 10 strains of Enterobacter cloacae were determined by daily transfer for 7 days to fresh medium containing twofold serial dilutions of the antibiotics. Development of resistance to ceftriaxone was the most rapid; this was followed by ceftazidime, cefpirome, and cefepime. Resistant variants selected by ceftriaxone and ceftazidime were cross-resistant and produced very high levels of beta-lactamase. On the other hand, resistant variants selected by cefepime and cefpirome often had moderately high levels of beta-lactamase and diminished levels of the 39- to 40-kDa porin protein.
摘要
通过将10株阴沟肠杆菌每日转接至含有抗生素两倍系列稀释液的新鲜培养基中，持续7天，测定了这些菌株对头孢曲松、头孢他啶、头孢吡肟和头孢匹罗的耐药性发展速率。对头孢曲松的耐药性发展最为迅速；其次是头孢他啶、头孢匹罗和头孢吡肟。由头孢曲松和头孢他啶选择出的耐药变体具有交叉耐药性，并产生非常高水平的β-内酰胺酶。另一方面，由头孢吡肟和头孢匹罗选择出的耐药变体通常具有中等高水平的β-内酰胺酶，且39至40 kDa孔蛋白的水平降低。
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