Bolodon V N, Krut'ko Iu V, Rozin V V, Chernitskiĭ E A
Biofizika. 1996 Mar-Apr;41(2):413-6.
The influence of different factors modifying erythrocyte membrane structure on the value of power index of doze dependence of photohemolysis of hematoporphyrin-sensitized erythrocytes has been investigated. It has been established that thermoinduced spectrin aggregation results in increase the index, whereas vesiculation under metabolic exhaustion of erythrocytes greatly decreases value n. A more considerable decrease of the parameter was observed when photohemolysis of erythrocytes was occurred in alkaline medium. It has been shown that the observed decrease of the power index in the latter case is not caused by pH-induced changes of photochemical reactions but by some dark processes. The decrease is possibly brought about by pH-induced conformational changes of protein band 3.
研究了不同因素对红细胞膜结构的修饰对血卟啉敏化红细胞光溶血剂量依赖性功率指数值的影响。已确定热诱导血影蛋白聚集会导致该指数增加，而红细胞代谢耗竭时的囊泡化会大大降低n值。当红细胞在碱性介质中发生光溶血时，观察到该参数有更显著的降低。结果表明，在后一种情况下观察到的功率指数降低不是由pH值引起的光化学反应变化所致，而是由一些暗过程引起的。这种降低可能是由pH值诱导的带3蛋白构象变化引起的。
