Parik T, Allikmets K, Teesalu R, Zilmer M
Department of Cardiology, University of Tartu, Estonia.
J Hypertens. 1996 Mar;14(3):407-10. doi: 10.1097/00004872-199603000-00019.
To evaluate oxidative stress markers in normo- and hyperinsulinaemic essential hypertension patients, and to relate these parameters to plasma glucose and insulin levels.
Diene conjugates, thiobarbituric acid reactive substances, iron-stimulated thiobarbituric acid reactive substances and anti-oxidative capacity of serum were detected in 32 untreated essential hypertension patients with normal glucose tolerance, divided into hyperinsulinaemic (n = 12, fasting plasma insulin level > 13.5 mU/l, means 2 SD of controls) and normo-insulinaemic (n = 20) subgroups, compared with 26 age- and body mass index-matched controls. Plasma glucose and insulin levels were measured during an oral glucose tolerance test.
Levels of lipid peroxidation products (diene conjugates, thiobarbituric acid reactive substances and iron-stimulated thiobarbituric acid reactive substances) were elevated and serum anti-oxidative capacity decreased both in hyper- and in normo-insulinaemic patients compared with those in controls, with no significant differences between the hypertensive subgroups. No independent correlations were detected between oxidative stress markers and fasting or stimulated plasma insulin and glucose levels. The essential hypertension patients were characterized by a lower fasting glucose: insulin ratio and enhanced plasma insulin response to oral glucose test compared with controls.
The results suggest that oxidative stress occurs, in addition to disturbances in glucose metabolism, in essential hypertension patients, thus potentially exposing them to increased risk of developing complications. Factors other than plasma insulin level are likely to contribute to oxidative stress in hypertensive patients with normal glucose tolerance.
评估正常胰岛素血症和高胰岛素血症原发性高血压患者的氧化应激标志物，并将这些参数与血糖和胰岛素水平相关联。
检测32例未经治疗的糖耐量正常的原发性高血压患者血清中的二烯共轭物、硫代巴比妥酸反应性物质、铁刺激的硫代巴比妥酸反应性物质以及抗氧化能力。这些患者分为高胰岛素血症亚组（n = 12，空腹血浆胰岛素水平> 13.5 mU/l，为对照组均值±2 SD）和正常胰岛素血症亚组（n = 20），并与26例年龄和体重指数匹配的对照组进行比较。在口服葡萄糖耐量试验期间测量血浆葡萄糖和胰岛素水平。
与对照组相比，高胰岛素血症和正常胰岛素血症患者的脂质过氧化产物水平（二烯共轭物、硫代巴比妥酸反应性物质和铁刺激的硫代巴比妥酸反应性物质）均升高，血清抗氧化能力降低，高血压亚组之间无显著差异。氧化应激标志物与空腹或刺激后的血浆胰岛素和葡萄糖水平之间未检测到独立相关性。与对照组相比，原发性高血压患者的特征是空腹血糖：胰岛素比值较低，口服葡萄糖试验后血浆胰岛素反应增强。
结果表明，原发性高血压患者除了存在糖代谢紊乱外，还存在氧化应激，因此可能使其发生并发症的风险增加。血浆胰岛素水平以外的因素可能导致糖耐量正常的高血压患者发生氧化应激。
