Valenta R, Steinberger P, Duchêne M, Kraft D
Institute of General and Experimental Pathology, AKH University of Vienna, Austria.
Immunol Cell Biol. 1996 Apr;74(2):187-94. doi: 10.1038/icb.1996.26.
It is known that allergic patients are frequently co-sensitized against different allergen sources. Progress made in the field of allergen characterization by molecular biological techniques has now revealed that sensitization against different allergen sources can be explained as cross-reactivity of IgE antibodies with structurally and immunologically related components present in these allergen sources. This review defines groups of cross-reactive plant allergens with significant sequence homology. The similarities among allergens may facilitate allergy diagnosis by using a few representative cross-reactive allergens to determine the patient's IgE reactivity profile (allergogram). According to that typing, a few cross-reactive allergens, carrying most of the relevant IgE epitopes, may then be selected for patient-tailored specific therapy.
众所周知，过敏患者常常对不同的过敏原来源产生共同致敏。分子生物学技术在过敏原表征领域取得的进展现已表明，对不同过敏原来源的致敏可解释为IgE抗体与这些过敏原来源中存在的结构和免疫相关成分的交叉反应。本综述定义了具有显著序列同源性的交叉反应性植物过敏原组。过敏原之间的相似性可能有助于通过使用一些代表性的交叉反应性过敏原确定患者的IgE反应谱（过敏图）来进行过敏诊断。根据该分型，然后可以选择携带大多数相关IgE表位的一些交叉反应性过敏原用于患者定制的特异性治疗。
