Otsuki M, Maeda M, Yuu H, Yamasaki T, Okano K
Clin Chim Acta. 1977 Jun 15;77(3):349-57. doi: 10.1016/0009-8981(77)90240-6.
The nature of the postoperative hyperamylasemia in 27 patients undergoing open-heart surgery was investigated. An increase in serum amylase activity was found in 56% of the patients. Isoamylase analysis revealed that the rise was in the salivary-type isoamylase in all of these patients. Since the level of serum amylase activity was increased in the postoperative state with prolongation of extracorporeal circulation, it is conceivable that cellular hypoxia due to inadequate tissue perfusion may cause disturbances in cellular metabolism with a release of intracellular amylase. The finding of the salivary-type amylase in normal lung tissue, transient salivary-type hyperamylasemia in acute respiratory distress and increased amylase activity of the salivary-type in serum specimens from the left atrium compared to those from the right ventricle suggest that the origin of the amylase responsible for the transient postoperative hyperamylasemia in the salivary-type is due to the amylase released from lung tissues under hypoxia during and after operation.
对27例接受心脏直视手术患者术后高淀粉酶血症的性质进行了研究。56%的患者血清淀粉酶活性升高。同工酶分析显示，所有这些患者的升高均为唾液型同工酶。由于术后血清淀粉酶活性水平随着体外循环时间的延长而升高，可以推测组织灌注不足导致的细胞缺氧可能会引起细胞代谢紊乱并释放细胞内淀粉酶。在正常肺组织中发现唾液型淀粉酶、急性呼吸窘迫时出现短暂的唾液型高淀粉酶血症以及与右心室血清标本相比左心房血清标本中唾液型淀粉酶活性增加，提示导致术后短暂唾液型高淀粉酶血症的淀粉酶来源是手术期间及术后缺氧状态下肺组织释放的淀粉酶。
