Naidu S H, Beredjiklian P, Adler L, Bora F W, Baker D G
Department of Orthopaedic Surgery, Pennsylvania State University, Hershey, USA.
J Hand Surg Am. 1996 May;21(3):496-500. doi: 10.1016/s0363-5023(96)80369-8.
Silicone elastomer particles (Silastic silicone elastomer, Dow Corning, Midland, MI), polymethylmethacrylate particles, and monosodium urate particles smaller than 10 microns were injected into a rat subcutaneous air pouch lined with synovial membrane-like cells. Inflammatory exudate from the air pouch was retrieved at 6 hours, 24 hours, 48 hours, and 72 hours after injection. White blood cell count, tumor necrosis factor, and prostaglandin E2 were measured in the exudate. White blood cell and tumor necrosis factor levels in the exudate were the highest for the silicone group at 6 and 24 hours. Prostaglandin E2 was also significantly higher in the silicone group at 24 hours. We conclude that the acute inflammation is particle-type specific and that Silicone elastomer particles are acutely inflammatory.
将硅酮弹性体颗粒（道康宁公司生产的Silastic硅酮弹性体，位于密歇根州米德兰）、聚甲基丙烯酸甲酯颗粒以及小于10微米的尿酸钠颗粒注射到衬有滑膜样细胞的大鼠皮下气囊中。在注射后6小时、24小时、48小时和72小时收集气囊中的炎性渗出液。检测渗出液中的白细胞计数、肿瘤坏死因子和前列腺素E2。在6小时和24小时时，硅酮组渗出液中的白细胞和肿瘤坏死因子水平最高。在24小时时，硅酮组的前列腺素E2也显著更高。我们得出结论，急性炎症具有颗粒类型特异性，且硅酮弹性体颗粒具有急性炎症性。
