Sağlam F, Onan U, Soydinç M, Yilmaz O, Kiraç K, Sever M S
University of Istanbul, Faculty of Dentistry, Department of Periodontology, Turkey.
J Periodontol. 1996 May;67(5):528-31. doi: 10.1902/jop.1996.67.5.528.
Cyclosporin a is an endecapeptide that has been used clinically since 1978 as an immunosuppressant agent. Although cyclosporine appears to be uniformly beneficial in the treatment of a wide variety of disorders, its use may result in a number of side effects. One of the most important adverse effects is gingival overgrowth. This report relates a case of severe gingival overgrowth in a 31-year-old female who had received cyclosporine therapy in conjunction with a kidney transplant. Because of the severe gingival overgrowth, we analyzed a biopsy, which was positive for human papillomavirus. The case was treated and followed for 18 months.
环孢素A是一种十一肽，自1978年以来一直作为免疫抑制剂在临床上使用。尽管环孢素在治疗多种疾病方面似乎都有一致的益处，但其使用可能会导致一些副作用。最重要的副作用之一是牙龈增生。本报告讲述了一名31岁女性的严重牙龈增生病例，该女性在接受肾移植的同时接受了环孢素治疗。由于严重的牙龈增生，我们对活检进行了分析，结果显示人乳头瘤病毒呈阳性。该病例接受了治疗并随访了18个月。
