Miller R R, Jick H
Clin Pharmacol Ther. 1977 Jul;22(1):1-6. doi: 10.1002/cpt19772211.
Among 26,294 hospitalized patients monitored by the Boston Collaborative Drug Surveillance Program (BCDSP), 8,948 (34%) received at least one antibiotic, and none were diagnosed as having drug-induced colitis to in-hospital antibiotic exposure. Seven patients who had taken antibiotics as outpatients, however, were admitted with antibiotic-associated colitis. Six of these patients had taken lincomycin prior to the onset of symptoms; one had taken ampicillin. Six of the patients were hospitalized at a New Zealand hospital and one at a hospital in Canada. The five patients with lincomycin-associated colitis at the New Zealand hospital were admitted over an 11-month period. Severe colitis due to antibiotics has been a rare event in the BCDSP experience, especially in the United States.
在波士顿药物监测协作计划（BCDSP）监测的26294名住院患者中，8948名（34%）至少接受了一种抗生素治疗，且无一例因住院期间使用抗生素而被诊断为药物性结肠炎。然而，有7名门诊使用过抗生素的患者因抗生素相关性结肠炎入院。这些患者中有6名在症状出现前使用过林可霉素；1名使用过氨苄青霉素。其中6名患者在新西兰一家医院住院，1名在加拿大一家医院住院。新西兰医院的5名林可霉素相关性结肠炎患者在11个月内入院。在BCDSP的经验中，抗生素导致的严重结肠炎一直是罕见事件，在美国尤为如此。
