Yamamoto M, Hibi H, Miyake K
Department of Urology, Nagoya University School of Medicine.
Nagoya J Med Sci. 1996 Mar;59(1-2):25-9.
Antisperm antibodies are one of the important factors in male infertility caused by vasal obstructions. To investigate the incidence of serum antisperm antibodies in patients with various kinds of seminal tract obstructions, we retrospectively analyzed the sera of 60 patients using the indirect immunobead test (IBT) to find serum antisperm antibodies. Immunoglobulin (Ig)G and IgA class antisperm antibodies were positive in 55% and 18% of those patients with a vasal obstruction caused by inguinal herniorrhaphy and in 60% and 20% of vasectomized patients respectively; whereas these antibodies were positive in 13% and 0% of those patients with an epididymal obstruction of unknown etiology and in 8% and 3% of those patients with congenital bilateral absence of the vas deferens (CBAVD). The incidence of antisperm antibodies was significantly higher in patients with a vasal obstruction than in those with an epididymal obstruction (p < 0.001).
抗精子抗体是输精管阻塞所致男性不育的重要因素之一。为研究各类精道阻塞患者血清抗精子抗体的发生率，我们采用间接免疫珠试验（IBT）对60例患者的血清进行回顾性分析，以检测血清抗精子抗体。在因腹股沟疝修补术导致输精管阻塞的患者中，55%的患者免疫球蛋白（Ig）G类抗精子抗体呈阳性，18%的患者IgA类抗精子抗体呈阳性；在输精管结扎患者中，这两类抗体呈阳性的比例分别为60%和20%；而在病因不明的附睾梗阻患者中，这两类抗体呈阳性的比例分别为13%和0%，在先天性双侧输精管缺如（CBAVD）患者中，这两类抗体呈阳性的比例分别为8%和3%。输精管阻塞患者抗精子抗体的发生率显著高于附睾梗阻患者（p < 0.001）。
