Beischer N A, Wein P, Sheedy M T, Dargaville R M
Department of Obstetrics and Gynaecology, University of Melbourne, Australia.
Diabetes Care. 1996 Jun;19(6):653-5. doi: 10.2337/diacare.19.6.653.
We wished to test the hypothesis that the diagnosis of diabetes in women with previous gestational diabetes in our follow-up program had altered the ratio of IDDM to NIDDM in our pregnant population.
We identified all pregnancies managed at the Mercy Hospital for Women in Melbourne, Australia, from 1971 to 1994 that were complicated by prepregnancy diabetes. In these 374 pregnancies, we identified those women who had previously been diagnosed with gestational diabetes mellitus (GDM). The changing prevalences over time of prepregnancy IDDM and NIDDM, as well as the contribution to both of these conditions made by women who had previously had GDM, were calculated.
Over the period of the study, there was an increase in the prevalence of IDDM from 0.15 to 0.44% (chi 2 for trend, P < 0.00001) and NIDDM from 0.03 to 0.11% (chi 2 for trend, P = 0.0001). The proportion of all women with diabetes with NIDDM did not change significantly (16.7-20%). There was a progressive increase in the proportion of women with NIDDM who had had GDM (from 8.3 to 39.1%), but the trend was not statistically significant (P = 0.059). Women with NIDDM were more likely (20 of 64, 31.3%) to have had gestational diabetes in the past than women with IDDM (12 of 310, 3.9%, odds ratio 11.3, 95% CI 5.16-24.7, P < 0.0001).
Despite finding relatively young women to have NIDDM, our GDM follow-up clinic has not yet altered significantly the ratio of IDDM to NIDDM in pregnancy.
我们希望检验这样一个假设，即在我们的随访项目中，既往有妊娠期糖尿病的女性被诊断为糖尿病后，会改变我们妊娠人群中胰岛素依赖型糖尿病（IDDM）与非胰岛素依赖型糖尿病（NIDDM）的比例。
我们确定了1971年至1994年在澳大利亚墨尔本仁慈妇女医院管理的所有合并孕前糖尿病的妊娠情况。在这374例妊娠中，我们确定了那些既往被诊断为妊娠期糖尿病（GDM）的女性。计算了孕前IDDM和NIDDM随时间变化的患病率以及既往有GDM的女性对这两种情况的贡献。
在研究期间，IDDM的患病率从0.15%增加到0.44%（趋势检验卡方值，P<0.00001），NIDDM的患病率从0.03%增加到0.11%（趋势检验卡方值，P = 0.0001）。所有糖尿病女性中NIDDM的比例没有显著变化（16.7 - 20%）。既往有GDM的NIDDM女性比例逐渐增加（从8.3%增至39.1%），但该趋势无统计学意义（P = 0.059）。与IDDM女性（310例中的12例，3.9%）相比，NIDDM女性过去患妊娠期糖尿病的可能性更大（64例中的20例，31.3%，优势比11.3，95%可信区间5.16 - 24.7，P<0.0001）。
尽管发现相对年轻的女性患有NIDDM，但我们的GDM随访门诊尚未显著改变妊娠人群中IDDM与NIDDM的比例。
