沃纳综合征中的早衰现象不累及中枢神经系统。

Premature aging in Werner's syndrome spares the central nervous system.

作者信息

Postiglione A, Soricelli A, Covelli E M, Iazzetta N, Ruocco A, Milan G, Santoro L, Alfano B, Brunetti A

机构信息

Department of Clinical and Experimental Medicine, University of Naples Federico II, Italy.

出版信息

Neurobiol Aging. 1996 May-Jun;17(3):325-30. doi: 10.1016/0197-4580(96)00033-4.

DOI:10.1016/0197-4580(96)00033-4

PMID:8725892

Abstract

Werner's Syndrome is a rare genetic disease, characterized by premature aging of many tissues and organs. We studied the brain morphology and function in two patients with Werner's syndrome to assess the possible involvement of the central nervous system in this premature aging process. The two patients (brother and sister, respectively) were studied by magnetic resonance imaging (MRI) and angiography (MRA), single photon emission computed tomography (SPECT) with (99mTc)-d,l-hexamethyl propilene amine oxime (HMPAO), positron emission tomography (PET) with 2(18F)-Fluoro-2-deoxyglucose (FDG), electroencephalography (EEG), and electromyography (EMG). Some of these investigations were also repeated after 1 year. The results of all these studies were normal. The premature aging process in patients with Werner's syndrome, while affecting most tissues, seems to spare the central nervous system.

摘要

沃纳综合征是一种罕见的遗传性疾病，其特征是许多组织和器官过早衰老。我们研究了两名沃纳综合征患者的脑形态和功能，以评估中枢神经系统在这种过早衰老过程中可能受到的影响。这两名患者（分别为兄妹）接受了磁共振成像（MRI）和血管造影（MRA）、使用（99mTc）-d，l-六甲基丙烯胺肟（HMPAO）的单光子发射计算机断层扫描（SPECT）、使用2-（18F）-氟-2-脱氧葡萄糖（FDG）的正电子发射断层扫描（PET）、脑电图（EEG）和肌电图（EMG）检查。其中一些检查在1年后也重复进行。所有这些研究结果均正常。沃纳综合征患者的过早衰老过程虽然影响了大多数组织，但似乎未累及中枢神经系统。