Kruisbeek A M, Amsen D
Division of Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Curr Opin Immunol. 1996 Apr;8(2):233-44. doi: 10.1016/s0952-7915(96)80062-8.
To understand how the immune system manages to disarm potentially harmful T cells with reactivity against self-antigens, many immunologists have turned to model systems in which transgenic expression of TCRs, foreign antigens, or both, allows visualization of otherwise undetectable mechanisms. Recent data have offered several new insights into the variables that dictate the mechanism for tolerance employed by peripheral T cells. Some of these mechanisms can also dampen ongoing immune responses against foreign antigens and provide a strikingly powerful supplement to the primary mechanism of tolerance, thymic clonal deletion.
为了了解免疫系统如何设法解除那些对自身抗原有反应性的潜在有害T细胞的武装，许多免疫学家转向了模型系统，在这些系统中，TCR、外来抗原或两者的转基因表达能够使原本无法检测到的机制可视化。最近的数据为决定外周T细胞所采用的耐受机制的变量提供了一些新的见解。其中一些机制还可以抑制针对外来抗原的正在进行的免疫反应，并为主要的耐受机制——胸腺克隆清除，提供一种极为强大的补充。
