Savel'eva K V, Kamenskiĭ A A, Ashmarin I P
Zh Vyssh Nerv Deiat Im I P Pavlova. 1996 Mar-Apr;46(2):301-8.
Behavioural effects of NO precursor L-arginine (Arg) were studied. Arg was shown to impair place learning with food reinforcement in the maze task. Arg was introduced per os immediately after the training session, i.e., 24 hours prior to the next session in doses of 50, 100 and 250 mg/kg. Intake of Arg in the dose of 100 mg/kg induced the most effective learning inhibition. Special tests demonstrated that Arg in the applied doses did not influence food motivation. Analysis of Arg effects suggests that the observed behavioural changes are probably due to the excess NO synthesis from Arg in brain tissues which, in turn, may result in cell damage.
研究了一氧化氮前体L-精氨酸（Arg）的行为效应。结果表明，在迷宫任务中，精氨酸会损害食物强化的位置学习。在训练 session 后立即经口给予精氨酸，即在下次 session 前24小时，剂量分别为50、100和250mg/kg。100mg/kg剂量的精氨酸摄入引起了最有效的学习抑制。特殊测试表明，所应用剂量的精氨酸不影响食物动机。对精氨酸效应的分析表明，观察到的行为变化可能是由于脑组织中精氨酸过度合成一氧化氮所致，进而可能导致细胞损伤。
