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[作为衡量不同品系大鼠内源性阿片系统活性指标的施特劳布尾抬高反应频率比较]

[A comparison of the frequency of the Straub tail elevation reaction as a measure of the activity of the endogenous opiate system in rats of different strains].

作者信息

Kolpakov V G, Barykina N N, Ponomarev I Iu, Gevorgian M M

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1996 Mar-Apr;46(2):342-7.

PMID:8726568
Abstract

Stress-induced and exploratory activity-related Straub tail elevation was studied as a probable measure of endogenous opiate system activity in rats from catalepsy-susceptible GC strain as well as PM+ and PM- strains bred from Wistar stock for the presence and absence of predisposition to a stereotyped hyperkinesis with pendulum-like movements. All the three strains were characterized by lower incidence of Straub tail elevation than in the control Wistar stock. Moreover, the PM+ strain demonstrated a lower incidence of the studied reaction than PM- the difference between the strains being manifested during exploratory activity but not in immobilization stress.

摘要

研究了应激诱导和探索活动相关的施特劳布尾抬高,以此作为对来自易患僵住症的GC品系以及从Wistar种群培育而来的PM +和PM -品系大鼠内源性阿片系统活性的一种可能衡量指标,这些品系分别存在和不存在具有钟摆样运动的刻板性运动亢进倾向。与对照Wistar种群相比,所有这三个品系的施特劳布尾抬高发生率均较低。此外,PM +品系的研究反应发生率低于PM -品系,品系之间的差异在探索活动期间表现出来,但在固定应激中未表现出来。

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Zh Vyssh Nerv Deiat Im I P Pavlova. 1996 Mar-Apr;46(2):342-7.
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