Barykina N N, Alekhina T A, Chekasov I L, Kolpakov V G
Genetika. 1984 Nov;20(11):1818-23.
Within outbred Wistar stock, the pendulum movements are found to be inherited in what may be considered as a dominant mono- or oligogenic mode of inheritance with incomplete penetrance. This indicates that the albinism only permits the manifestation of the pendulum movements, which are also controlled by some other gene or genes. The pendulum movements show a positive genetic relation to catalepsy, although this relation is not strong: the proportion of animals with pendulum movements is 23% in the control population and 32% in F12-F16 bred for catalepsy (p less than 0.05). Within the latter, the proportion of animals with pendulum movements was 43% in the progeny of parents with phenotypically expressed catalepsy, and 29% in the progeny of phenotypically "normal" animals (p less than 0.01). The frequency of audiogenic seizures was 32% in the control population and 17% in F8-F16 bred for catalepsy (p less than 0.001). A genetic model is proposed to account for the paradoxical situation, where pendulum movements have a positive genetic relation both to catalepsy and audiogenic epilepsy, the catalepsy being at the same time negatively related to epilepsy.
在远交系Wistar种群中，发现钟摆运动以一种不完全外显的、可能被视为显性单基因或寡基因的遗传模式遗传。这表明白化病仅允许钟摆运动的表现，而钟摆运动也受其他一些基因控制。钟摆运动与僵住症呈正遗传关系，尽管这种关系并不强烈：在对照种群中，有钟摆运动的动物比例为23%，而在为诱发僵住症而培育的F12 - F16代中为32%（p小于0.05）。在后者中，表型表现出僵住症的亲代的子代中，有钟摆运动的动物比例为43%，而表型“正常”动物的子代中这一比例为29%（p小于0.01）。在对照种群中，声源性惊厥的发生率为32%，而在为诱发僵住症而培育的F8 - F16代中为17%（p小于0.001）。提出了一个遗传模型来解释这种矛盾的情况，即钟摆运动与僵住症和声源性癫痫都呈正遗传关系，而僵住症同时与癫痫呈负相关。
