Hyett J, Moscoso G, Papapanagiotou G, Perdu M, Nicolaides K H
Harris Birthright Centre for Fetal Medicine, King's College Hospital Medical School, London, UK.
Ultrasound Obstet Gynecol. 1996 Apr;7(4):245-50. doi: 10.1046/j.1469-0705.1996.07040245.x.
Pathological examination of trisomic fetuses with increased nuchal translucency thickness at 11-13 weeks of gestation demonstrated a high prevalence of cardiac defects and abnormalities of the great arteries. This study reports the pathological findings observed from the examination of the heart and great arteries of 21 chromosomally normal fetuses with increased nuchal translucency. In 19 of the 21 cases there were abnormalities; the commonest was narrowing of the aorta at the level of the isthmus and immediately above the aortic valve. This finding is different from that in case of trisomy 21, where narrowing of the isthmus is associated with an increased diameter of the aortic valve. These findings suggest that abnormalities of the heart and great arteries may be implicated in the pathogenesis of increased nuchal translucency not only in trisomic fetuses but also in chromosomally normal fetuses. It can be implied that increased nuchal translucency thickness at 10-14 weeks of gestation may prove to be a useful marker for the identification of fetal cardiac abnormalities.
对孕11至13周时颈部半透明厚度增加的三体胎儿进行病理检查发现，心脏缺陷和大动脉异常的发生率很高。本研究报告了对21例颈部半透明增加的染色体正常胎儿的心脏和大动脉检查所观察到的病理结果。21例中有19例存在异常；最常见的是主动脉峡部水平及主动脉瓣上方紧邻处狭窄。这一发现与21三体胎儿不同，21三体胎儿的峡部狭窄与主动脉瓣直径增加有关。这些发现表明，心脏和大动脉异常可能不仅在三体胎儿，而且在染色体正常的胎儿中，都与颈部半透明增加的发病机制有关。可以推测，孕10至14周时颈部半透明厚度增加可能被证明是识别胎儿心脏异常的有用标志物。
