Sorvari H, Soininen H, Pitkänen A
Department of Neurology, University of Kuopio, Finland.
J Comp Neurol. 1996 May 27;369(2):188-208. doi: 10.1002/(SICI)1096-9861(19960527)369:2<188::AID-CNE2>3.0.CO;2-#.
Calretinin is a calcium-binding protein that colocalizes with GABA in the cerebral cortex and hippocampus of the rat and the monkey. In the present study, we investigated the distribution of calretinin-immunoreactive cells and fibers in the human amygdaloid complex. A conspicuous feature was the high density of calretinin neurons in the human amygdala. The highest densities of the calretinin-immunoreactive neurons were observed in the anterior cortical nucleus, accessory basal nucleus, amygdalohippocampal area, and in the nucleus of the lateral olfactory tract. The paralaminar nucleus, central nucleus, medial nucleus, and the periamygdaloid cortex contained the lowest densities of calretinin neurons. In most of the amygdaloid areas, the calretinin cells had the appearance of aspiny or sparsely spiny local circuit neurons. However, in the amygdalohippocampal area, we found also densely spined dendrites. The cortical areas and the central nucleus were characterized by intense neuropil labeling, while the deep nuclei contained a high density of calretinin-immunoreactive fibers and terminals. Calretinin immunoreactivity was also found in the intra-amygdaloid fiber bundles, stria terminalis, and in the ventral amygdalofugal pathway. This suggests that in addition to the local circuit neurons, calretinin immunoreactivity is also located in neurons that connect the amygdaloid complex with the other brain areas. The distribution and morphological characteristics of calretinin-immunoreactive neurons differed from those of another calcium-binding protein, parvalbumin, in the human amygdala (Sorvari et al. [1995] J. Comp. Neurol. 360:185-212). This suggests that these two calcium-binding proteins are located in different populations of neurons.
钙视网膜蛋白是一种钙结合蛋白，在大鼠和猴子的大脑皮层及海马体中与γ-氨基丁酸（GABA）共定位。在本研究中，我们调查了人类杏仁核复合体中钙视网膜蛋白免疫反应性细胞和纤维的分布。一个显著特征是人类杏仁核中钙视网膜蛋白神经元的高密度分布。在皮质前核、副基底核、杏仁体海马区和外侧嗅束核中观察到钙视网膜蛋白免疫反应性神经元的最高密度。层旁核、中央核、内侧核和杏仁周皮质中钙视网膜蛋白神经元的密度最低。在大多数杏仁核区域，钙视网膜蛋白细胞呈现为无棘或棘突稀疏的局部回路神经元。然而，在杏仁体海马区，我们也发现了密集有棘的树突。皮质区域和中央核的特征是神经毡标记强烈，而深部核团含有高密度的钙视网膜蛋白免疫反应性纤维和终末。在杏仁核内纤维束、终纹和杏仁腹侧离束通路中也发现了钙视网膜蛋白免疫反应性。这表明除了局部回路神经元外，钙视网膜蛋白免疫反应性也存在于将杏仁核复合体与其他脑区相连的神经元中。人类杏仁核中钙视网膜蛋白免疫反应性神经元的分布和形态特征与另一种钙结合蛋白小白蛋白不同（索尔瓦里等人，[1995年]《比较神经学杂志》360:185 - 212）。这表明这两种钙结合蛋白位于不同的神经元群体中。
