Linderkamp O, Mader T, Butenandt O, Riegel K P
Eur J Pediatr. 1977 Jun 1;125(2):135-41. doi: 10.1007/BF00489986.
Plasma volume was measured using Evans blue dye and 125iodinated human serum albumin (RIHSA) simultaneously in order to evaluate the accuracy of a simplified Evans blue method recommended by Nielsen and Nielsen (1962). 9 studies were performed in 8 newborn infants weighing 1.07 to 2.85 kg and 16 studies in 14 patients aged 6 months to 14 years suffering from severe circulatory disturbances. In 20 studies, plasma volumes measured by Evans blue and by RIHSA agreed within +/-5%, and in all the studies within +/-10%. The Evans blue method yielded higher plasma volumes than the RIHSA method in 19 instances. The mean difference (paired t-test) was only significant in newborn infants (+4.0+/-3.6%; P less than 0.05). The disappearance rates of Evans blue exceeded that of RIHSA in 16 studies, but this was only significant in the patients older than 6 months (+2.3+/-4.2%/h; P less than 0.05).
为评估Nielsen和Nielsen（1962年）推荐的简化伊文思蓝方法的准确性，同时使用伊文思蓝染料和125碘标记的人血清白蛋白（RIHSA）测量血浆容量。对8名体重1.07至2.85千克的新生儿进行了9项研究，对14名年龄在6个月至14岁、患有严重循环障碍的患者进行了16项研究。在20项研究中，用伊文思蓝和RIHSA测量的血浆容量在±5%范围内一致，在所有研究中在±10%范围内一致。在19例中，伊文思蓝方法得出的血浆容量高于RIHSA方法。平均差异（配对t检验）仅在新生儿中显著（+4.0±3.6%；P<0.05）。在16项研究中，伊文思蓝的消失率超过了RIHSA，但这仅在6个月以上的患者中显著（+2.3±4.2%/小时；P<0.05）。
