Feng L, Han S, Zhao Y, Wang L, Chen J
Department of Environmental Science and Engineering, Nanjing University, P. R. China.
Chem Res Toxicol. 1996 Apr-May;9(3):610-3. doi: 10.1021/tx950166r.
A general and practical relation has been established between structure and activity of organic chemicals based on target theory. This relation was tested by examining the correlations between the acute toxicity and the physicochemical properties for fathead minnow, which showed that this relation can explain the observed toxicity data and phenomena successfully. The equations are then used to estimated the acute toxicity data of organic chemicals, and the predicted values are close to observed values.
