Chang C J, Nelson J S
Beckman Laser Institute and Medical Clinic Department of Surgery, University of California at Irvine 92715, USA.
Ann Plast Surg. 1996 Apr;36(4):394-7. doi: 10.1097/00000637-199604000-00012.
Peutz-Jeghers syndrome is an eponym for circumscribed mucocutaneous melanosis in association with gastrointestinal polyposis. Irregular pigmented macules of varying size and color can be found on the perioral skin, lip vermillion border, buccal mucosa, palate, and tongue. Previous treatments, such as surgical excision, cryosurgery, electrodesiccation, dermabrasion, and carbon dioxide or argon laser ablation commonly result in incomplete removal, scarring, or changes in normal pigmentation. The Q-switched ruby laser used at 694 nm, a wavelength well absorbed by melanin relative to other optically absorbing structures in skin, causes highly selective destruction of pigment-laden cells. In addition, the 20-nanosecond pulse duration produced by this laser approximates the thermal relaxation time for melanosomes, thereby confining the energy to the target. The Q-switched ruby laser produces clinically significant fading of mucocutaneous melanosis in association with Peutz-Jeghers syndrome without complications often seen with other therapeutic modalities.
黑斑息肉综合征是以局限性黏膜皮肤黑变病合并胃肠道息肉病而命名的疾病。在口周皮肤、唇红缘、颊黏膜、腭部和舌部可发现大小和颜色各异的不规则色素沉着斑。以往的治疗方法，如手术切除、冷冻手术、电干燥法、磨皮术以及二氧化碳或氩激光消融术，通常会导致切除不完全、瘢痕形成或正常色素沉着改变。调Q红宝石激光以694纳米波长使用，相对于皮肤中其他光吸收结构而言，该波长能被黑色素很好地吸收，可导致富含色素的细胞被高度选择性地破坏。此外，该激光产生的20纳秒脉冲持续时间接近黑素小体的热弛豫时间，从而将能量限制在目标部位。调Q红宝石激光可使黑斑息肉综合征相关的黏膜皮肤黑变病在临床上显著消退，且不会出现其他治疗方式常见的并发症。
