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开发抗金黄色葡萄球菌疫苗的前景。

The prospects for developing a vaccine against Staphylococcus aureus.

作者信息

Lee J C

机构信息

Dept of Medicine, Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

出版信息

Trends Microbiol. 1996 Apr;4(4):162-6. doi: 10.1016/0966-842x(96)10021-4.

DOI:10.1016/0966-842x(96)10021-4
PMID:8728611
Abstract

Staphylococcus aureus is an important bacterial pathogen with multiple virulence factors. The prevalence of antibiotic resistance among clinical isolates means that new vaccine strategies to prevent staphylococcal infections are needed. An ideal vaccine would induce antibodies to prevent bacterial adherence, promote opsonophagocytic killing by leukocytes and neutralize toxic secreted proteins.

摘要

金黄色葡萄球菌是一种具有多种毒力因子的重要细菌病原体。临床分离株中抗生素耐药性的普遍存在意味着需要新的疫苗策略来预防葡萄球菌感染。理想的疫苗应诱导产生抗体以防止细菌黏附，促进白细胞的调理吞噬杀伤作用并中和分泌的毒性蛋白。

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