Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.
Nat Rev Microbiol. 2014 Aug;12(8):585-91. doi: 10.1038/nrmicro3308. Epub 2014 Jul 7.
Staphylococcus aureus is a highly successful bacterial pathogen owing to its abundance of cell surface and secreted virulence factors. It is estimated that 30% of the population is colonized with S. aureus, usually on mucosal surfaces, and methicillin-resistant S. aureus is a major public health concern. There have been multiple attempts to develop an S. aureus vaccine using one or more cell surface virulence factors as antigens; all of these vaccine trials have failed. In this Opinion article, we suggest that an over-reliance on rodent models and a focus on targeting cell surface components have been major contributing factors to this failure.
金黄色葡萄球菌是一种高度成功的细菌病原体，因为它拥有丰富的细胞表面和分泌的毒力因子。据估计，有 30%的人口定植有金黄色葡萄球菌，通常在黏膜表面，耐甲氧西林金黄色葡萄球菌是一个主要的公共卫生关注点。人们曾多次尝试使用一种或多种细胞表面毒力因子作为抗原来开发金黄色葡萄球菌疫苗；所有这些疫苗试验都失败了。在这篇观点文章中，我们认为过度依赖于啮齿动物模型和专注于靶向细胞表面成分是导致这一失败的主要因素。
