Kato T, Frei B, Heinrich M, Sticher O
Department of Pharmacy, Swiss Federal Institute of Technology, Zurich, Switzerland.
Phytochemistry. 1996 Mar;41(4):1191-5. doi: 10.1016/0031-9422(95)00765-2.
Three new hydroperoxysterols, 24-hydroperoxy-4 alpha, 14 alpha- dimethylcholesta-8,25-dien-3 beta-ol, 25-hydroperoxy-4 alpha, 14 alpha-dimethylcholesta-8,23-dien-3 beta-ol and 25-hydroperoxycycloart-23-en- 3 beta-ol, have been isolated from the aerial parts of Xanthosoma robustum, besides 24-hydroperoxycycloart-25-en-3 beta-ol, 4 alpha, 14 alpha-dimethylcholesta-8,24-dien-3 beta-ol and cycloartenol. Additionally, the two new diols, 4 alpha, 14 alpha-dimethylcholesta-8,25-dien-3 beta, 24-diol and 4 alpha, 14 alpha-dimethylcholesta-8,23-dien-3 beta, 25-diol were obtained from the first two hydroperoxysterols, respectively, by reduction with triphenylphosphine. The structures have been defined by chemical and spectroscopic studies. The four hydroperoxysterols exhibited antibacterial activities against Escherichia coli, Bacillus subtilis and Micrococcus luteus.
除了24-氢过氧化环阿尔廷-25-烯-3β-醇、4α,14α-二甲基胆甾-8,24-二烯-3β-醇和环阿尔廷醇外，从粗壮黄肉芋的地上部分分离出了三种新的氢过氧化甾醇，即24-氢过氧化-4α,14α-二甲基胆甾-8,25-二烯-3β-醇、25-氢过氧化-4α,14α-二甲基胆甾-8,23-二烯-3β-醇和25-氢过氧化环阿尔廷-23-烯-3β-醇。此外，从前两种氢过氧化甾醇分别通过用三苯基膦还原得到了两种新的二醇，即4α,14α-二甲基胆甾-8,25-二烯-3β,24-二醇和4α,14α-二甲基胆甾-8,23-二烯-3β,25-二醇。通过化学和光谱研究确定了其结构。这四种氢过氧化甾醇对大肠杆菌、枯草芽孢杆菌和藤黄微球菌均表现出抗菌活性。
