Lisboa C, Villafranca C, Pertuzé J, Leiva A, Repetto P
Departamento de Enfermedades Respiratorias, P Universidad Católica de Chile, Santiago.
Rev Med Chil. 1995 Sep;123(9):1108-15.
The clinical role of inspiratory muscle training (IMT) in chronic obstructive pulmonary disease (COPD) has not been established, because data on its clinical effect is scarce and controversial. To further investigate these aspects we studied 20 COPD patients (FEV1 37 +/- 3% P) who were randomly and double blindly trained for 30 minutes a day during 10 weeks using a threshold inspiratory trainer with either 30% (group 1) or 10% (group 2) of PIMax as a training load. The training load was crossed after each patient completed 10 weeks of training. Effects were assessed through changes in PIMax, dyspnea through the transition dyspnea index (ITD) and the respiratory effort with Borg's score. Walking capacity was measured with the six minutes walking distance test (6WD) and depression symptoms with Beck's score. Daily life activities were also assessed. Results showed that after 10 weeks of IMT, PIMax increased in both groups (p < 0.05), dyspnea improved in group 1 as compared to group 2 (p < 0.04), 6WD increased significantly in patients of group 1, who also complained of less dyspnea (p < 0.05). Depression scores fell significantly in group 2. Daily activities improved more in group 1. After the crossover patients in group 1 disclosed a significant deterioration in PIMax whereas group 2 disclosed significant improvements in PIMax, dyspnea and 6WD. We conclude that IMT using a threshold device with 30% PIMax is a useful procedure for the treatment of severe COPD patients.
吸气肌训练(IMT)在慢性阻塞性肺疾病(COPD)中的临床作用尚未明确,因为关于其临床效果的数据稀少且存在争议。为了进一步研究这些方面,我们对20例COPD患者(FEV1为37±3%预计值)进行了研究,这些患者被随机、双盲分组,使用阈值吸气训练器,以最大吸气压(PIMax)的30%(第1组)或10%(第2组)作为训练负荷,每天训练30分钟,为期10周。每位患者完成10周训练后,训练负荷进行交叉。通过最大吸气压的变化、采用过渡性呼吸困难指数(ITD)评估的呼吸困难以及Borg评分评估的呼吸努力来评估效果。采用6分钟步行距离测试(6WD)测量步行能力,采用贝克评分评估抑郁症状。还对日常生活活动进行了评估。结果显示,IMT训练10周后,两组患者的最大吸气压均升高(p<0.05),第1组的呼吸困难较第2组有所改善(p<0.04),第1组患者的6WD显著增加,且呼吸困难症状减轻(p<0.05)。第2组的抑郁评分显著下降。第1组的日常活动改善更为明显。交叉训练后,第1组患者的最大吸气压显著恶化,而第2组患者的最大吸气压、呼吸困难和6WD均有显著改善。我们得出结论,使用最大吸气压30%的阈值装置进行吸气肌训练是治疗重度COPD患者的有效方法。