Villanueva C L, Zavala C, Alcayaga M P
Servicio de Medicina, Hospital del Salvador, Santiago de Chile.
Rev Med Chil. 1995 Sep;123(9):1129-32.
Two diabetic patients with unusual high levels of glycosylated hemoglobin measured by ion exchange chromatography are described. Further studies revealed a persistence of fetal hemoglobin in both cases. This condition produces falsely high levels of glycosylated hemoglobin, when ion exchange chromatography is used. These cases may be overtreated with risk of hypoglycemia. Patients with inappropriate levels of glycosylated hemoglobin should be investigated for hemoglobinopathies.
描述了两名通过离子交换色谱法测得糖化血红蛋白水平异常高的糖尿病患者。进一步研究发现这两个病例中均存在胎儿血红蛋白持续存在的情况。当使用离子交换色谱法时,这种情况会导致糖化血红蛋白水平出现假性升高。这些病例可能会因低血糖风险而接受过度治疗。糖化血红蛋白水平异常的患者应检查是否患有血红蛋白病。