Spatz H, Spatz N
Bioquímicos, Laboratorio de Psiquiatría Biológica, Buenos Aires, Argentina.
Acta Psiquiatr Psicol Am Lat. 1995 Sep;41(3):230-6.
We have studied the content of platelet serotonin in 31 depressive patients free of medication and in 29 controls. The depressive patients have been selected according to clinic diagnosis and to urinary phenylethylamine (PEA) and total phenylacetic acid (PAA) values, because low levels of these two substances are for us almost a constant in endogenous depressive patients. For the control group we selected 23 out of 29 cases studied, which had all urinary PEA and PAA values within the normal range published by us previously. In this group platelet serotonin content was of 527-900 ng/10 9 platelets with a mean of 698 +/- 125 ng/10 9 platelets. In the depressive group, taking account of platelets serotonin content we could differentiate two subgroups. In a group of 19 patients we found lower values, 157-513 ng/10 9 platelets with a mean of 407 +/- 102 ng/10 9. In the other 13 patients group we found platelet serotonin levels similar to those of the control group, 552-780 ng 10 9 platelets with a mean of 658 +/- 93 ng/10 9 platelets. Accepting blood platelets as models for serotoninergic nerve terminals, we suppose that the response of depressive patients to serotonin reuptake blockers treatment should be different in both subgroups, which is at present matter of study in our laboratory.
我们研究了31名未服药的抑郁症患者及29名对照者的血小板5-羟色胺含量。抑郁症患者是根据临床诊断以及尿苯乙胺（PEA）和总苯乙酸（PAA）值挑选出来的，因为对我们来说，这两种物质水平较低在内源性抑郁症患者中几乎是一个恒定现象。对于对照组，我们从29例研究对象中挑选出23例，其尿PEA和PAA值均在我们之前公布的正常范围内。该组血小板5-羟色胺含量为527 - 900 ng/10⁹血小板，平均为698 ± 125 ng/10⁹血小板。在抑郁症组中，根据血小板5-羟色胺含量可区分出两个亚组。在一组19名患者中，我们发现其值较低，为157 - 513 ng/10⁹血小板，平均为407 ± 102 ng/10⁹。在另一组13名患者中，我们发现血小板5-羟色胺水平与对照组相似，为552 - 780 ng/10⁹血小板，平均为658 ± 93 ng/10⁹血小板。若将血小板视为5-羟色胺能神经末梢的模型，我们推测抑郁症患者的两个亚组对5-羟色胺再摄取阻滞剂治疗的反应应该不同，这目前是我们实验室正在研究的课题。
