糖尿病大鼠葡萄糖转运蛋白基因mRNA表达的研究
A study of mRNA expression of glucose transporter gene in rats with diabetes mellitus.
作者信息
Wang H, Chen J, Chai J
机构信息
Department of Endocrinology, Jiangsu Province Hospital, Nanjing.
出版信息
Chin Med J (Engl). 1995 Dec;108(12):892-4.
The study was proceeded on the mRNA expression of the GLUT-1 and GLUT-4 gene in the alloxan-induced diabetic rats by the method of dot-blot hybridization analysis. The results showed that the levels of the GLUT-4 mRNA expression were reduced in the muscle tissue of the diabetic rats while its levels in the same tissue of insulin treated diabetic rats increased. It was suggested that the reduced GLUT-4 mRNA expression which could affect its posttranslational products may be one of the causes of the insulin resistance.
采用斑点杂交分析方法，对四氧嘧啶诱导的糖尿病大鼠中葡萄糖转运蛋白1（GLUT-1）和葡萄糖转运蛋白4（GLUT-4）基因的mRNA表达进行了研究。结果显示，糖尿病大鼠肌肉组织中GLUT-4 mRNA表达水平降低，而胰岛素治疗的糖尿病大鼠同一组织中的GLUT-4 mRNA水平升高。提示GLUT-4 mRNA表达降低可能影响其翻译后产物，这可能是胰岛素抵抗的原因之一。
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