Jain S K, McVie R, Jaramillo J J, Palmer M, Smith T, Meachum Z D, Little R L
Department of Pediatrics, Louisiana State University Medical Center, Shreveport 71130, USA.
Lipids. 1996 Mar;31 Suppl:S87-90. doi: 10.1007/BF02637057.
Among many factors, elevated lipids and lipid peroxide levels in blood are major risk factors in the development of cardiovascular disease in diabetic patients. This study has examined whether oral supplementation of vitamin E, an antioxidant, has any effect on blood lipid peroxidation products (LP) and lipid profile of diabetic patients. Thirty-five diabetics(D) were supplemented with DL-alpha-tocopherol (E) capsule (orally, 100 IU/d) or placebo (P) for three months in double-blind clinical trials. Plasma E was analyzed by HPLC and LP by the thiobarbituric acid-reactivity; serum lipids by auto-analyzer. Data were analyzed using paired t-test and Wilcoxon Signed Rank Test. Vitamin E supplementation significantly lowered LP and lipid levels in diabetic patients; there were no differences in these parameters after P supplementation. There were no differences in the duration of diabetes and ages of D between P- and E- supplemented groups. This study suggests that vitamin E supplementation significantly lowers blood LP and lipid levels in diabetic patients.
在众多因素中，血液中脂质和脂质过氧化物水平升高是糖尿病患者发生心血管疾病的主要危险因素。本研究检测了口服抗氧化剂维生素E是否对糖尿病患者的血脂过氧化产物（LP）和血脂状况有任何影响。在双盲临床试验中，35名糖尿病患者（D组）被给予DL-α-生育酚（E）胶囊（口服，100 IU/天）或安慰剂（P组），为期三个月。血浆维生素E通过高效液相色谱法分析，LP通过硫代巴比妥酸反应性分析；血清脂质通过自动分析仪分析。数据采用配对t检验和Wilcoxon符号秩检验进行分析。补充维生素E可显著降低糖尿病患者的LP和血脂水平；补充安慰剂后这些参数无差异。补充安慰剂组和补充维生素E组在糖尿病病程和糖尿病患者年龄方面无差异。本研究表明，补充维生素E可显著降低糖尿病患者的血液LP和血脂水平。
