Laugharne J D, Mellor J E, Peet M
University Department of Psychiatry, Northern General Hospital, Sheffield, United Kingdom.
Lipids. 1996 Mar;31 Suppl:S163-5. doi: 10.1007/BF02637070.
In a controlled study of red cell membrane fatty acids in patients with schizophrenia, substantial depletions of fatty acids from both the n-6 and n-3 series were demonstrated. Arachidonic acid and docosahexaenoic acid were particularly depleted. In a separate study, dietary analysis revealed no deficiency of fatty acid intake in this patient group, but greater intake of n-3 fatty acids was associated with less severe symptomatology. Dietary supplementation for six weeks with 10 g per day of concentrated fish oil (MaxEPA) led to significant improvement in schizophrenic symptoms. This clinical improvement was related to the increased level of n-3 fatty acids in red cell membranes. These findings form part of a growing body of research data suggestive of an abnormality in cell membrane fatty acid composition in schizophrenia. The preliminary evidence for clinically effective dietary manipulation to correct such an abnormality opens up novel and exciting therapeutic possibilities.
在一项针对精神分裂症患者红细胞膜脂肪酸的对照研究中，n-6和n-3系列脂肪酸均出现了显著减少。花生四烯酸和二十二碳六烯酸的减少尤为明显。在另一项研究中，饮食分析显示该患者群体不存在脂肪酸摄入不足的情况，但摄入更多的n-3脂肪酸与症状较轻相关。每天补充10克浓缩鱼油（MaxEPA），持续六周，可使精神分裂症症状得到显著改善。这种临床改善与红细胞膜中n-3脂肪酸水平的升高有关。这些发现构成了越来越多研究数据的一部分，表明精神分裂症患者细胞膜脂肪酸组成存在异常。通过临床有效的饮食干预来纠正这种异常的初步证据，开启了全新且令人兴奋的治疗可能性。
