Leiros C P, Sterin-Borda L, Goren N, Borda E S
Centro de Estudios Farmacologicos y Botanicos (CEFYBO) - CONICET y Catedra de Farmacologia, Facultad de Odontologia, Universidad de Buenos Aires, Argentina.
Acta Physiol Pharmacol Ther Latinoam. 1995;45(4):201-12.
This review regards the main functional characteristics of hearts subjected to an autoimmune response, focusing especially on the role of T lymphocytes and autoantibodies in the development of cardiac dysfunction. Evidence of a strong association in the onset and time-course of immune response and cardiac dysfunction is presented and the results are viewed comparatively with myocarditis models induced by heart, parasite or virus inoculation. Cardiac damage is evaluated regarding various aspects, namely histologic, immunologic, biochemical, pharmacologic, physiologic. Finally, the model, for its characteristics of resulting from an autoimmune response against the heart with functional consequences, has proved its usefulness to study neuroimmune interaction, mainly the immune to nervous direction, as autoantibodies and T cell-derived factors have a role in cardiac failure.
本综述关注遭受自身免疫反应的心脏的主要功能特征，尤其聚焦于T淋巴细胞和自身抗体在心脏功能障碍发展过程中的作用。文中呈现了免疫反应与心脏功能障碍在发病及病程方面存在强关联的证据，并将结果与通过心脏、寄生虫或病毒接种诱导的心肌炎模型进行了比较。从组织学、免疫学、生物化学、药理学、生理学等多个方面评估了心脏损伤。最后，由于该模型是由针对心脏的自身免疫反应导致并产生功能后果，已证明其在研究神经免疫相互作用（主要是免疫向神经方向的作用）方面的有用性，因为自身抗体和T细胞衍生因子在心力衰竭中发挥作用。
