Busch R, Mellins E D
Joseph Stokes Jr Research Institute, Children's Hospital of Philadelphia, PA 19104, USA.
Curr Opin Immunol. 1996 Feb;8(1):51-8. doi: 10.1016/s0952-7915(96)80105-1.
Over the past year, several important advances have been made in understanding the mechanisms by which class II MHC glycoproteins acquire endosomal peptides inside antigen-presenting cells. Recent progress in the study of class II antigen presentation includes the identification of ligands from which invariant chain protects class II molecules in pre-endosomal compartments, an improved understanding of how invariant chain inhibits antigenic peptide binding, and the appreciation that HLA-DM (a factor important for antigen presentation in vivo) can act as a catalyst for peptide exchange.
在过去的一年里，在理解II类主要组织相容性复合体（MHC）糖蛋白在抗原呈递细胞内获取内体肽的机制方面取得了几项重要进展。II类抗原呈递研究的最新进展包括鉴定在内体前区室中不变链保护II类分子的配体，对不变链如何抑制抗原肽结合有了更好的理解，以及认识到HLA-DM（体内抗原呈递的一个重要因子）可作为肽交换的催化剂。
